MOTS-C

The signal your mitochondria send to the rest of you.

Includes syringes & alcohol pads

HPLC-verified ≥99% purity · Certificate of Analysis

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Dose Range

5–10 mg

Route

Subcutaneous

Frequency

3×/week

Stability

30 days refrigerated

The Science

A peptide written inside the mitochondrion itself.

MOTS-c is one of the few peptides encoded not in the nucleus, but within the mitochondrial genome. Its discovery reframed the mitochondrion — long considered a silent power plant — as an active communicator, sending molecular signals throughout the body in response to metabolic stress.

Research has connected MOTS-c with insulin sensitivity, exercise capacity, and the metabolic flexibility that defines healthspan. It is, quite literally, the voice of your power plants speaking to the rest of your cells.

Researched Benefits

Mitochondrial Biogenesis

Supports the production of new, functional mitochondria.

Insulin Sensitivity

Researched for its role in glucose regulation and metabolic signaling.

Exercise Capacity

May enhance the body's response to physical work.

Metabolic Homeostasis

Helps maintain the balance between energy input and output.

The Protocol

Reconstitution & Administration

Reconstitute with bacteriostatic water and store refrigerated. Most protocols cycle 4–6 weeks on, 2–4 weeks off.

Suggested Dose

5–10 mg

Frequency

3×/week

This information is for research context. Any decisions about personal use — including dosing, timing, and cycle length — should involve a licensed medical provider familiar with your individual health.

What to Expect

The Timeline

Protocols typically run 5–10mg subcutaneously three times per week for 4–6 weeks, followed by a 2–4 week break. Effects on energy and recovery are often noticed within the first cycle; metabolic markers are best evaluated over longer arcs.

Stack It With

Often paired with: